Applications are invited from suitably qualified and experienced candidates in the prescribed format (to be copied on a plain paper) for the temporary post(s) mentioned below in the research project titled PROTOCOL N01199, an open-label, multicenter, follow-up trial to evaluate the long-term safety and efficacy of brivaracetam used as adjunctive treatment at a flexible dose up to a maximum of 200 mg/day in subjects aged 16 years or older suffering from epilepsy

Post: Clinical Research Coordinator- 1

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A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Post: Regulatory CMC Associate Manager-II

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The Institute of Chemical Technology (ICT) Mumbai was established as the Department of Chemical Technology on 1st October, 1933 by the University of Mumbai, through active support of industries and philanthropists. The Institute was most popularly known as UDCT, Mumbai. Research has been an integral part of ICT since its inception and it has created over 500 first generation entrepreneurs. The UDCT grew significantly in stature and was granted autonomy under UGC regulations by the University of Mumbai and further converted in to an Institute on 26th January, 2002. Under the World Bank TEQIP programme, the Maharashtra government granted it full autonomy in June 2004.

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T.V.M college of pharmacy is one of the reputed Pharmacy colleges in Karnataka established in 1985 under the aegis of V.V Sangha's Bellary . It is located in sprawling campus of over 5 acres of land with a built up area of 40,000 Sq ft. The college has contributed to hundreds of pharmacists to the society who carved a name for themselves in various fields of pharmacy profession in India and abroad.

Post: Lecturer in Pharmacy Practice for Pharm.D course

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Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative centre of higher education offering high-quality teaching and research. Balanced study and career paths in a wide variety of disciplines encourage the 27,000 students and researchers to develop their own individual talents. Belonging to the best research universities in Europe and joining forces with prestigious partner universities and networks, the University of Groningen is truly an international place of knowledge.

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Shivaji University, established in 1962, is named after the Great Maratha Warrior and founder of the Maratha empire Chhatrapati Shivaji. It was inaugurated on 18th November, 1962 by Dr. Radhakrishnan, the then President of India. One of the major objectives behind foundation of this University was to cater to the regional needs of South Maharashtra. The jurisdiction of the University is spread over three districts viz. Kolhapur, Sangli and Satara with strength of about 2,00,000 students studying in 225 affiliated colleges and recognised institutes.

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Applications are invited on plain paper along with full Bio-Data, Mark sheets, certificates, testimonials and a recent passport size photograph for the following posts under the DBT research project entitled “Development of seaweeds biorefinery and pilot demonstration of bioethanol production” for a period of three years or till the tenure of the project. All posts are on temporary basis.

Post: Research Associate, Junior Research Fellow, field assistant

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Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.

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ABOUT AUTHORS:
Swati k. Nagar*¹, Dr. Harsha V. Patel¹, Dr.Vishnu A. Patel², Vinod V. Siju^3
1Indukaka Ipcowala College of pharmacy, New V.V.Nagar
²ARCP, Vallabh vidhyanagar
³Anand Pharmacy College, Anand.
*swati.nagar28@gmail.com

ABSTRACT-
The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties and solubility of olmesartan medoxomil (OLM) in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: ratio of carrier to coating material (X₁) and drug concentration (X₂)  on angle of repose (Y₁), hardness(Y₂), saturation solubility study (Y₃) and cumulative percentage release at 10 min (CPR _10min)(Y₄) of formulation using five  level two factor central composite design. The quadratic model generated by the design is of the form: Y = A₀ + A₁X₁ + A₂X₂ + A₃X₁X₂ + A₄X₁² + A₅X₂² + E, where Y is the measured response associated with each factor level combination. Contour and response surface plots were depicted based on the equation given by the model. The optimized formula yields observed values close to the predicted values. The liquisolid tablets were formulated with liquid vehicles, poly ethylene glycol 400 (PEG400) at five drug concentrations, 10% w/w, 15% w/w, 20% w/w, 25% w/w and 30% w/w. Avicel PH102 was used as a carrier material, Aerosil 200 as a coating material and cross carmellose sodium as a disintegrant.In-vitro drug dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation (olmezest), in simulated intestinal fluid (pH 6.8). The drug release rates of LS compacts were higher as compared to directly compressed tablets, which show significant benefit of LS in increasing wetting properties and surface area of drug available for dissolution. From this study it concludes that the LS technique is a promising alternative for improvement of dissolution property.

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About Author:
Alex Martin
Department of Pharmaceutical Chemistry,
St. Joseph’s College of Pharmacy
University of Health Sciences, Cherthala-688524 (Kerala), India.
aalexmartin@rediffmail.com

Abstract
Oxadiazole is a five membered heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. It exists in four isomeric forms. One of its four isomers 1,3,4-oxadiazole exhibited  a wide range of biological activities which includes anti-bacterial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic, enzyme inhibitor, vasodilatory, antifungal, cytotoxic, anti-inflammatory, analgesic, hypolipidemic,  anticancer, insecticidal activities etc. The present review has basic information about 1,3,4-oxadiazole and its biological activities.

Oxadiazoles is a heterocyclic ring and is considered to be derived from furan by the replacement of two methane (-CH=) groups by two nitrogen (-N=) atoms. There are four possible isomers of Oxadiazole, depending on the positions of hetero atoms  and they are named as 1,2,3; 1,2,4; 1,2,5; 1,3,4-oxadiazoles. 1,2,4-Oxadiazole, 1,2,5-Oxadiazole, and 1,3,4-Oxadiazole are known, but the 1,2,3-isomer is unstable and reverts to the diazoketone tautomer. The stable oxadiazoles appear in a variety of pharmaceutical drugs including raltegravir, butalamine, fasiplon,  oxolamine, and pleconaril.

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