Indian Institute of Chemical Technology, Hyderabad is a premier R&D Institute in India. The Institute had its origin as the Central Laboratories for Scientific & Industrial Research (CLSIR), established in 1944 by the then Government of Hyderabad State. After integration of Hyderabad State with the Indian Union, the laboratory expanded with its growing activities. The main building was formally opened by Pandit Jawaharlal Nehru, the then Prime Minister of India on January 2, 1954. In 1956, the Central Laboratories came under the aegis of the Council of Scientific & Industrial Research (CSIR), New Delhi and was renamed Regional Research Laboratory, Hyderabad (RRL-H).

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The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC, Kharghar, Navi Mumbai is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India. It is registered under the Societies Registration Act (1860) and the Bombay Public Trust Act (1950).

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Post: Programme Manager (Technical)

No.of post: UR-1

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The history of Jamia Hamdard begins with the establishment of a small Unani clinic in the year 1906 by Hakeem Hafiz Abdul Majeed, one of the well-known practitioners of Unani System of Medicine of his time. Hakeem Hafiz Abdul Majeed had a vision of making the practice of Unani Medicine into a scientific discipline so that Unani medicines could be dispensed in a more efficacious manner to patients.

Post: Junior Research Fellow (Bioinformatics)

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Established in 1889, the Indian Veterinary Research Institute (IVRI) is one of the premier research institutions dedicated to livestock research and development of the region. The institute with faculty strength of more than 275 has a major mandate of research, teaching, consultancy and technology transfer activities. The institute with its long scientific heritage has always enjoyed a certain prestige, a tradition all of its own.

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ABOUT AUTHORS:
Sarthak B. Dave*, Dr. Dipen K. Sureja.
Department of Pharmaceutical Chemistry,
Shree H. N. Shukla Institute of Pharmaceutical Education & Research,
Rajkot, Gujarat, India
*davesarthak@ymail.com

ABSTRACT:
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon a, ß-unsaturated carbonyl system. Mainly chalcone are synthesized by Claisen-schmidt condensation reaction (Cross-aldol reaction). Chalcones are well known intermediates for synthesizing various heterocyclic compounds. Chalcones, precursors of open chain flavonoids and isoflavonoids present in edible plants, and their derivatives have attracted increasing attention due to numerous potential pharmacological applications. They have displayed a broad spectrum of pharmacological activities. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity. The present review highlights the recently synthesized Chalcones and their derivatives possessing important pharmacological activities.

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ABOUT AUTHORS:
Venkatesh. J , M. Singaiah Chowdary*, Haritha. D, Anuroop , Dr. V.V.L.N Prasad, Anjani Prasad Reddy. V.
Department of Pharmaceutical Analysis and Quality assurance,
School of pharmacy, Anurag Group of Institutions, Venkatapur (V).
Ghatkesar (M), Rangareddy (D)
*chowdary.mannam1@gmail.com

ABSTRACT:
A new simple, rapid, specific, accurate, precise and novel reverse phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the simultaneous estimation of atazanavir and ritonavir in the combined pharmaceutical dosage form. The chromatographic separation for Atazanavir and Ritonavir were achieved with mobile phase containing mixed phosphate buffer (pH 4.0) and acetonitrile (45:55 % v/v), Symmetry C18 (4.6 x 100mm, 3.5mm, Make: ACE)at 5°C and UV detection at 237 nm. The compounds were eluted in the isocratic mode at a flow rate of 0.9 ml min^-1. The retention times of atazavir 4.29 ± 0.09 min and ritonavir at 5018 ± 0.09 min. The above method was validated in terms of linearity, accuracy, precision, LOD, LOQ etc. in accordance with ICH guidelines.

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